Using smart nanopolymers to kill old cells
NanoMIPs developed by MIP Diagnostics in collaboration with the University of Leicester have demonstrated their ability to target senescent cells, both in vitro and vivo. Such nanoMIPs were made to recognise one of the proteins abundant in on the surface of old cells and then tagged with a fluorescent molecule to aid in their detection. Also, these nanoMIPs were loaded with senolytic drugs and were able to selectively kill senescent cells.
These advancements, published online in Nanoscale Horizons (2019, DOI: 10.1039/C8NH00473K), have been possible thanks to a multidisciplinary team lead by Dr Salvador Macip (Department of Molecular and Cell Biology), Dr Francesco Canfarotta (MIP Diagnostics) and professor Sergey Piletsky (Chemistry Department)
This is the first targeted nanoparticle designed against old cells and has the potential to be used as a diagnostic and therapeutic tool in humans. Furthermore, thanks to the generic nature of the proprietary imprinting process used in this research, MIP Diagnostics can offer the possibility to design custom-made nanoMIPs against other clinically relevant targets.
‘Detecting and targeting senescent cells using molecularly imprinted nanoparticles’ is available to read online now.